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Exscientia, now part of Recursion, is a company focused on leveraging artificial intelligence (AI) for the development of medicines. Their primary aim is to create effective drugs more efficiently by using AI technologies in every stage of drug development, from target identification to drug design and clinical trials. Below are significant aspects of their operations based on their detailed company-authored content:

Core Offerings:

• Patient-First AI: The company emphasizes a patient-first approach by using real patient tissue and engineered AI platforms to enhance target selection, drug design, experimentation, and clinical assessment.

• Precision Target: In the initial drug discovery phase, selecting the correct targets is seen as fundamental. The company applies machine learning models to genetic data to identify promising disease-target associations and ensure that the targets are "druggable" with small molecules.

• Precision Design: This involves using AI to streamline the molecular design process, focusing on creating balanced molecules that fulfill various clinical requirements efficiently. This process integrates generative design and active learning to enhance drug discovery outcomes.

• Precision Experiment: To refine AI models and verify therapeutic profiles, the company maintains advanced laboratories with cutting-edge technologies such as surface plasmon resonance (SPR) and x-ray crystallography, offering a feedback loop between experiments and AI predictions.

• Precision Medicine: The company's approach in oncology involves directly testing on live patient tissues, analyzing data at the single cell level. Notably, the EXALT-1 clinical study proved that functional precision oncology can prospectively improve patient outcomes.

Internal and Partnered Pipeline:

• Clinical Trials: The pipeline includes various stages of drug discovery, such as Phase 1/2 trials for several conditions, including solid tumors and inflammatory diseases. For example, a CDK7 inhibitor for solid tumors and a PKC-theta inhibitor for inflammatory diseases are in the clinical trial phase.

• Partnerships: They hold both wholly owned and milestone-based partnerships to expand their drug discovery efforts into more therapeutic areas beyond oncology.

Company Vision and Infrastructure:

• The integration of AI into drug creation aims to redefine the economics of drug discovery, making the process more efficient and cost-effective.
• Exscientia maintains a substantial lab space to support its innovative research and development activities, fostering an intersection of AI and experimental science.

Corporate Policies and Social Responsibility:

• The company has laid out various policies, including privacy, anti-slavery, and expanded access policies. These reflect their commitment to ethical practices and compliance with relevant regulations.
• The company encourages the transparency of concerns through an anonymous whistleblower system and upholds ethical interaction with suppliers and customers as per their code of conduct.

Recent Developments:

• The merger with Recursion indicates a strategic move to combine resources, potentially paving the way to becoming a more robust AI-driven drug discovery entity known as a TechBio company. This move aligns with the vision to blend technological advances with biological innovation effectively.

Communication and Information Access:

• They provide channels for investors, media, and the public to stay updated on developments and corporate information. They are also reachable through structured contact methods for inquiries related to partnership, media, and career opportunities.

Overall, Exscientia (Recursion) represents an integration of precision, technology, and patient-centric focus in drug discovery. This approach aims to accelerate the creation of efficacious and safe medicinal solutions.